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Heat Shock Cognate Protein 70, Recombinant, Bovine (HSC70, Heat Shock Protein 73, HSP73)

Cat no: H1830-25A

Heat Shock Cognate Protein 70, Recombinant, Bovine (HSC70, Heat Shock Protein 73, HSP73)

In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. One class of stress proteins, termed the Hsp70 family, is comprised of multiple members, all of which bind ATP in vitro, but which are localized within different intracellular compartments. These include: i) the constitutive Hsc70 (or cognate) present within the cytosol/nucleus; ii) the highly stress-inducible Hsp70 present within the cytosol/nucleus/nucleolus; iii) the constitutive glucose regulated 78kD (or BiP) protein present within the lumen of the endoplasmic reticulum; and iv) the glucose regulated 75kD protein present within the mictochondrial matrix. Members of the Hsp70 family are thought to function as

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SPECIFICATIONS

Catalog Number

H1830-25A

Size

20ug

Form

Supplied as a liquid in 10mM Tris-HCl, pH 7.5, 150mM sodium chloride, 3mM magnesium chloride, 1mM DTT.

Purity

> 95% as determined by SDS-PAGE analysis.

References

1. Ellis, R.J., Semin. Cell Biol. 1: 1-9 (1990). 2. Gething, M.-J., and Sambrook, J., Nature 355: 33-45 (1992). 3. Schlesinger, M.J. and Ryan, C., Protein Sequence 2: 1356-1360 (1993). 4. Wilbanks, S.M., DeLuca-Flaherty, C. and McKay, D.B., J. Biol. Chem. 269: 12893-12898 (1994).

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