Heat Shock Protein 110 (HSP110)

Hsp110 belongs to a family of large stress proteins known as the Hsp110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied Hsp70 family. They share 30-33% amino acid identity, mostly in the conserved ATP-binding domain (1). \nHsp110 cooperates with Hsp70 in protein folding in the eukaryotic cytosol (2). In mammals, Hsp110 is constitutively expressed, but exhibits particularly high levels in the brain. Both Hsp70 and Hsp110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of Hsp110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70 (3). Studies also suggest that Hsp110 can be used in heat shock protein-based cancer immunotherapy (4). \n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot:1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H1833-10B

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov, NHP, Sheep, Yeast/Fun

Form

Supplied as a liquid in PBS, pH7.2, 50% glycerol and 0.09% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Lee-Yoon D., et al. (1995) J Biol Chem. 270:15725-15733. 2. Dragovic Z., et al. (2006) EMBO J. 25:2519-2528. 3. Nakamura J., et al. (2008) Stroke. 39(10):2853-2859. 4. Subject D.R. (2001) Health Research Inc. Report number AS90893:1-84.

Additional Info

Recognizes hamster hsp110. Species Crossreactivity: human, monkey, rat, mouse, bovine, sheep, yeast.