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Heat Shock Protein 27, (HSP27, MKBP, Heat Shock Protein beta-1, HspB1, Heat Shock 27kD Protein, Stress-responsive Protein 27, SRP27, Estrogen-regulated 24kD Protein, 28kD Heat Shock Protein)

Cat no: H1830-53H

Heat Shock Protein 27, (HSP27, MKBP, Heat Shock Protein beta-1, HspB1, Heat Shock 27kD Protein, Stress-responsive Protein 27, SRP27, Estrogen-regulated 24kD Protein, 28kD Heat Shock Protein)

HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30% sequence identity to all other mammalian sHSPS (1). MKBP is known to associate specifically with myotonic dystrophy protein kinase (DMPK) in skeletal muscle. MKBP enhances the kinase activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique \nnature compared to other sHSps, in that the expression of MKBP is not induced by heat shock (2). In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction (1, 3). During stress, these complexes dissolve and MKBP

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SPECIFICATIONS

Catalog Number

H1830-53H

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 50% glycerol and 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Pinz I., et al. (2008) FASEB J. 22:84-92 2. Suzuki A., et al. (1998) J Cell Bio. 140(5):1113-1124. \n3. Sugiyama Y., et al. (2000) J Biol Chem. 275:1095-1104. 4. Oshita S.E., et al. (2010) Breast Cancer Res Treat. Epub:20087649.

Additional Info

Recognizes MKBP. Species Crossreactivity: human, mouse, rat.

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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