Heat Shock Protein 90 (hsp90)

HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms a and b, which share 85% sequence amino acid homology. The two isoforms of Hsp90, are expressed in the cytosolic compartment (1). Despite the similarities, \nHSP90a exists predominantly as a homodimer while HSP90b exists mainly as a monomer.(2) From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. (3-6) \nFurthermore, Hsp90 is highly conserved between species; having 60% and 78% amino acid similarity between mammalian and the corresponding yeast and Drosophila proteins, respectively. Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Despite it

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SPECIFICATIONS

Catalog Number

H1831-58M

Size

100ul

Applications

WB

Hosts

Rabbit

Form

Supplied as a lyophilized powder. Reconstitute with 100ul sterile water.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Nemoto T., et al. (1997) J.Biol Chem. 272:26179-26187. 2. Minami Y., et al. (1991), J.Biol Chem. 266:10099-10103. 3. Arlander S.J.H., et al. (2003) J Biol Chem 278:52572-52577. 4. Pearl H., et al. (2001) Adv Protein Chem 59:157-186. 5. Neckers L., et al. (2002) Trends Mol Med 8:S55-S61. \n6. Pratt W., Toft D. (2003) Exp Biol Med 228:111-133. 7. Pratt W., Toft D. (1997) Endocr Rev 18:306

Additional Info

Recognizes Hsp90. Species Crossreactivity: In salmonid fish a cross-reactive band at 40kDa is \nobserved. Antibody will also detect a human recombinant Hsp90 protein.