Hepatitis B Surface Antigen, Recombinant (HBsAg)

The hepatitis B virus is an important cause of acute and chronic liver disease. It is also the most common form of parenterally transmitted viral hepatitis. The virus is estimated to affect some 350 million people worldwide. Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries.\n\nHepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus. In some individuals the infection is not cleared and followed by persistent intracellular viral carriage that can lead to the development of hepatocelular carcinomas. There are currently 400 million HBV carriers worldwide making HBV one of the most common human pathogens.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilutions: Optimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

H1909-17C

Size

250ug

Applications

ELISA

Form

Supplied as a liquid in 10mM phosphate, 145mM sodium chloride, pH 6.4.

Purity

(same/more than)95% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.

References

1. [Establishment of transgenic mice of hepatitis B virus X gene (adr subtype) mediated by spermatogonial cells] Hu H, Li D, Yao Y, Sichuan Da Xue Xue Bao Yi Xue Ban 2003 Jan;34(1):145-7 2. Construction and biological activity assessment of core mutants of hepatitis B virus adr subtype. Chen WH, Lin YL, Luo KX, Di Yi Jun Yi Da Xue Xue Bao 2002 Mar;22(3):254-5 3. Establishment of transgenic mouse harboring hepatitis B virus (adr subtype) genomes. Hu YP, Hu WJ, Li JX, Yu HY, World J Gastroenterol 2001 Feb;7(1):111-4 4. Cloning and analysis of integrated hepatitis B virus DNA of the adr subtype derived from a human primary liver cell carcinoma. Fowler MJ, Thomas HC, J Gen Virol 1986 Apr;67 ( Pt 4):771-5 5. Biophysical characterization of the adr subtype of hepatitis B antigen and preparation of anti-r sera in rabbits. Gerin JL, Faust RM, J Immunol 1975 Jul;115(1):100-5.