Herpes Simplex Virus I (HSV I)

Herpes simplex type 1 (HSV-1) belongs to a family that includes HSV-2, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus amongst others. HSV-1 and HSV-2 are extremely difficult to distinguish from each other. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope, derived from the nuclear membrane of the last host, which is decorated with virus-specific glycoproteins spikes. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell.\n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry: Formalin-fixed, paraffin embedded and acetone-fixed, cryostat tissue sections. Incubate 30-60 minutes at RT. \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

H2033-11E

Size

6ml

Applications

IHC

Hosts

Rabbit

Form

Supplied as a liquid in PBS with sodium azide.

P Type

Pab

Purity

Purified

Isotype

IgG

References

1. Adams, et al., J. Pathol. 143: 241 (1984). 2. Vestergaard, et al., Acta Pathol. Microbiol. Scand. 87(B): 261 (1979).

Additional Info

Recognizes HSV 1 specific antigens and antigens common to HSV 1 and 2 virus. It reacts with all the major glycoproteins present in the viral envelope as well as with at least one core protein.