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Hexokinase, Type IV, Recombinant, Human (Glucokinase, Hexokinase 4, MODY2, HK4, HK IV)

Cat no: H2040-51

Hexokinase, Type IV, Recombinant, Human (Glucokinase, Hexokinase 4, MODY2, HK4, HK IV)

Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. In mammals, four distinct enzymes-types 1 to 4 hexokinases-have been identified. The enzyme is found in most cells, but there is tissue specificity for the particular type of hexokinase. Hexokinase4 is found in the liver and pancreatic beta-cells, where it is controlled by insulin (activation) and glucagon (inhibition). In pancreatic beta-cells, type IV enzyme acts as a glucose sensor to modify insulin secretion. Hexokinase4 is commonly called

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SPECIFICATIONS

Catalog Number

H2040-51

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol.

Purity

~95% by SDS PAGE

References

1. Jon E. et al.,(2003) J.Exp Biology. 206 : 2049-2057

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