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HGK (R430) pAb

HGK (R430) pAb

Cat no: BS2249

Supplier: Bioworld Technology, Inc.
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Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include NIK, KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, and GC kinase. NIK (Nck interacting kinase), like many of the STE20-like kinases, has been shown to activate the SAPK/JNK stress response pathway. Both the kinase domain and the C-terminal regulatory domain of NIK are required for full activation. NIK interacts with MEKK1 and is thought to act upstream of MEKK1 in the SAPK/JNK signaling pathway.
Catalogue number: BS2249
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunofluorescence, Western Blot
Size: 100ug/100ul
Swiss prot: O95819
Dilutions: WB: 1:500~1:1000 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 411-460 of Human HGK.
Species: HGK (R430) pAb detects endogenous levels of HGK protein.
Molecular weight: ~ 142 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Mitogen-activated protein kinase kinase kinase kinase 4; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; HPK/GCK-like kinase HGK; Nck interacting kinase; MEKKK 4; MAP4K4; NIK; KIAA0687
Additional info: For research use only, not for use in diagnostic procedure.

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