HGK (R430) Peptide

Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include NIK, KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, and GC kinase. NIK (Nck interacting kinase), like many of the STE20-like kinases, has been shown to activate the SAPK/JNK stress response pathway. Both the kinase domain and the C-terminal regulatory domain of NIK are required for full activation. NIK interacts with MEKK1 and is thought to act upstream of MEKK1 in the SAPK/JNK signaling pathway.

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SPECIFICATIONS

Catalog Number

BS2249P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide HGK (R430). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O95819

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2249 HGK (R430) pAb.

Alternative Names

Mitogen-activated protein kinase kinase kinase kinase 4; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; HPK/GCK-like kinase HGK; Nck interacting kinase; MEKKK 4; MAP4K4; NIK; KIAA0687