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HIPK2 Peptide

HIPK2 Peptide

Cat no: BS60320P

Supplier: Bioworld Technology, Inc.
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The Homeodomain-Interacting Protein Kinase (HIPK) family, which includes HIPK1, HIPK2, HIPK3, contains a conserved protein kinase domain as well as a separate domain that interacts with homeoproteins. HIPK2, the most highly characterized family member, is thought to act as a co-repressor of homeodomain transcription factors as HIPK2 has been shown to enhance the DNA binding of the NK-3 homeoprotein in vitro. It is regulated by a posttranslational modification of a ubiquitin-like protein, SUMO-1, via covalent bonding to a lysine residue on HIPK2. This is similar to the binding of SUMO-1 to PML and Sp100. The conjugation of SUMO-1 is thought to direct each of these proteins to nuclear bodies (NBs), which appear to play a role in autoimmunity and viral protection. HIPK2 is the first protein kinase to be directed to nuclear bodies in response to ubiquitin-like modification.
Catalogue number: BS60320P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q9H2X6
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide HIPK2. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Homeodomain-interacting protein kinase 2; hHIPk2
Additional info: This peptide can be used with studies using BS60320 HIPK2 pAb.

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