Histone H1.0 (R94) pAb

Histone H10 (H1 histone family, member 0) is a lysine rich member of the H1 family of linker histones. The H1 family of proteins interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histone H10 is a unique variant considered a replacement linker histone which is expressed and incorporated into chromatin in the absence of DNA replication. In contrast, the majority of somatic H1 histones are replication dependent variants found in proliferating cells. Histone H10 is expressed in cells that are in the terminal stages of differentiation or that have low rates of cell division. Unlike other differentiation-specific linker histones which demonstrate tissue and species-specific expression, Histone H10 is widely expressed in many tissues in most vertebrates.

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SPECIFICATIONS

Catalog Number

BS1916

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 61-110 of Human Histone H1.0.

Species

Histone H1.0 (R94) pAb detects endogenous levels of Histone H1.0 protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

P07305

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul