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Histone H3 (Di-Methyl K27) mAb

Histone H3 (Di-Methyl K27) mAb

Cat no: MB2027

Supplier: Bioworld Technology, Inc.
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Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination. These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression. In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms.
Catalogue number: MB2027
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P68431
Dilutions: WB: 1:500~1:2000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide conjugated to KLH derived from within residues 1-100 of Human Histone H3, di methylated at K27.
Species: Histone H3 (Di-Methyl K27) mAb detects endogenous levels of histone H3 only when di-methylated at Lys27.
Molecular weight: ~ 17 kDa
Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: H3K27me2
Additional info: For research use only, not for use in diagnostic procedure.

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