HLA-C, ID (HLA-C, HLAC, HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7)

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

036617

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Martin, M.P., et al. Immunogenetics 62 (11-12), 761-765 (2010) :\nStrange, A., et al. Nat. Genet. 42(11):985-990(2010)\nNoble, J.A., et al. Diabetes 59(11):2972-2979(2010)\nHoneyborne, I., et al. J. Virol. 84(21):11279-11288(2010)\nHealy, B.C., et al. Neurology 75(7):634-640(2010)

Additional Info

Human

Alternative Names

HLA-C, HLAC, HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7