HLA Class 2 Antigen DP (PE)

DP monomorphic antigen is expressed on hematopoietic progenitors, B lymphocytes, monocytes/ macrophages, dendritic cells, langerhans cells, activated T cells, some endothelial and epithelial cells, but not on resting T lymphocytes, erythrocytes and platelets. HLA-DP antigen is also expressed at high levels on B lymphocyte leukemic cells and cells of CML-LBC, at moderate levels on the cells of AML-M1/M2, M4 and M5, but not or little on the cells of AML-M3 and CML. This antibody might be used as valuable reagent in diagnosis and classification of leukemias.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution: \nFlow Cytometry: 100ul peripheral blood cells or 20ul/10e6 cells.\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 6 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

H6099-84G

Size

50Tests

Applications

FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 1% BSA, 0.05% sodium azide. Labeled with R-Phycoerythrin (PE).

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Shen DC., Chen Z., Bai JF., et al., 1990. Identification and preliminary application of HI43- A monoclonal antibody against human HLA-DP monomorphic antigen. Chinese J. of Microbiology and Immunology. 10(5): 291. 2. Knapp, W., B. Dorken, E.P. Rieber, et al., eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens. P?28 Oxford University Press, New York.

Additional Info

Recognizes a 28 and 34kD a, b heterodimer glycoprotein named class II major histocompatibility complex (or human leukocyte antigen) DP monomorphic antigen.