HLA Class 2 Antigen DR1 (HLA DR1 Class II, HLA-DR1)

HLA-DR1 belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28kD. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. The antibody MEM-267 specifically binds to the empty but not peptide-loaded form of HLA-DR1.\n\nApplications: \nSuitable for use in Flow Cytometry, ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H6099-97R

Size

100ug

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 15mM sodium azide, pH7.4.

P Type

Mab

Purity

Purified

Isotype

IgG2b

References

1. Gregory J. Carven, Sriram Chitta, Ivan Hilgert, Mia M. Rushe, Rick F. Baggio, Michelle Palmer, Jaime E. Arenas, Jack L. Strominger, Vaclav Horejsi, Laura Santambrogio, and Lawrence J. Stern (2004) Monoclonal Antibodies Specific for the Empty Conformation of HLA-DR1 Reveal Aspects of the Conformational Change Associated with Peptide Binding. J. Biol. Chem. 279, 16561–16570.

Additional Info

Recognizes human HLA-DR1.