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HLA-DOB Peptide

HLA-DOB Peptide

Cat no: BS5758P

Supplier: Bioworld Technology, Inc.
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Peptide (antigen) binding to major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II-Ig dimers and by the activity of MHC molecules HLA-DM and -DO. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility.
Catalogue number: BS5758P
Applications: Block/Neutralize/Inhibit
Swiss prot: P13765
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide HLA-DOB. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: HLA class II histocompatibility antigen, DO beta chain; MHC class II antigen DOB; HLA-DObeta; HLA-DO beta
Additional info: This peptide can be used with studies using BS5758 HLA-DOB pAb.

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