HLTF (Helicase-like Transcription Factor)

The HLTF (Helicase-like Transcription Factor) gene is a member of the family of genes that remove proteins that coil around DNA. HLTF proteins aid the stabilization and regulation of the production of proteins in the cell.\nInactivation of the HTLF gene may contribute to the transformation of normal colon cells into cancer cells.\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

H6170-01

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

As reported

P Type

Pab

Purity

Serum

References

1. Ding, H., et al. Characterization of a Helicase-Like Transcription Factor involved in the expression of the human plasminogen activator inhibitor-1 gene. DNA & Cell Bio. 15(6): p429-442, 1996. \n2. Ding, H., et al. Functional interactions between Sp1 or Sp3 and the Helicase-Like Transcription Factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. J. Biol. Chem. 274(28):19573-19580, 1999. (Western Blot, Immunoprecipitation, human/drosophila)\n3. Moinova, H.R., et al. HLTF gene silencing in human colon cancer. PNAS 99(7):4562-4567, 2002. (human)\n4. Komatsu, K. Human homoloue of S. pombe Rad9 interacts with BCL-2/BCL-xl and promotes apoptosis. Nat. Cell Biol. 2:1-6, 2000.\n5. Roos-Mattjus, P., et al. Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event. J. Biol. Chem. 277(46):43809-43812, 2002. (Western blot, human)

Additional Info

This antibody is specific for human HLTF protein. Species Crossreactivity: Human. Other species have not been tested.