HNF4(alpha) pAb

Cat no: BS6888

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

Hepatocyte nuclear factor 4(alpha) (HNF4(alpha)) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4(alpha), in association with PGC-1(alpha), activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4(alpha) gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4(alpha) have been linked to maturity-onset diabetes of the young (MODY).

Catalogue number:	BS6888
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P41235
Dilutions:	WB: 1:500~1:2000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Recombinant full length Human HNF4(alpha).
Species:	HNF4A pAb detects endogenous levels of HNF4A protein.
Molecular weight:	~ 52 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	HNF4A; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14;
Additional info:	For research use only, not for use in diagnostic procedure.

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HNF4(alpha) pAb

Cat no: BS6888

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