hnRNP Q (E268) Peptide

Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.

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SPECIFICATIONS

Catalog Number

BS1885P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide hnRNP Q (E268). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O60506

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1885 hnRNP Q (E268) pAb.

Alternative Names

GRY RBP; GRY-RBP; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; HNRPQ 1; HNRPQ; HNRPQ; HNRPQ1; NS1 associated protein 1; NS1-associated protein 1; NSAP 1; NSAP1; pp68; RP1 3J17.2; Synaptotagmin binding cytoplasmic RNA interacting protein; Synaptotagmin-binding; SYNCRIP;