Apolipoprotein C-I (apoC-I) is a 6.6 kDa apolipoprotein that is expressed primarily in the liver and activated when monocytes differentiate into macrophases. After being synthesized as a precursor with a length of 83 amino acids, apoC-I is processed to a single chain mature protein of 57 amino acids (1). It circulates in plasma and is a component of VLDL, IDL, and HDL (2 - 3). ApoC-I plays important modulatory roles in lipoprotein metabolism. It is an inhibitor of lipoprotein binding to the LDL receptor, LDL receptor-related protein, and VLDL receptor (4 - 5). It is the major plasma inhibitor of cholesteryl ester transfer protein and appears to interfere directly with fatty acid uptake (6 - 7).
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