HXK I pAb

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

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SPECIFICATIONS

Catalog Number

BS6105

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human HXK I.

Species

HXK I pAb detects endogenous levels of HXK I protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P19367

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~102 kDa

Alternative Names

BB404130; \nBrain form hexokinase; \ndea; \nEC 2.7.1.1; \nGlycolytic enzyme; \nHEXOKIN; \nHexokinase PI; \nHexokinase type I; \nHexokinase; tumor isozyme; \nHexokinase-1; \nHexokinase-A; \nHK I; \nHK1; \nHK1 tb; \nHk1-s; \nHK1-ta; \nHK1-tc; \nHKI; \nHXK1; \nHXK1; \nmHk1-s; \n