IFN-(alpha) pAb

Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide stimulated macrophages, and causes tumor necrosis when injected into tumour bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 a band following SDS PAGE under non reducing conditions. TNF alpha is closely related to the 25 a protein Tumour Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells.

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SPECIFICATIONS

Catalog Number

BS6427

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human IFN-(alpha).

Species

IFN-(alpha) pAb detects endogenous levels of IFN-(alpha) protein.

Dilutions

WB: 1:500~1:2000

Swiss Prot

P01562

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 20 kDa

Alternative Names

alpha-2a interferon; IFL; IFL interferon; IFN alpha; IFN; IFN leukocyte; IFN-alpha-1/13; IFNA@; IFNA1; IFNA1; IFNA13; IFNAP22; INFA 2; Interferon alpha 1; Interferon alpha 1/13; Interferon alpha 13; Interferon alpha D; Interferon alpha leukocyte; Interferon alpha-1/13; Interferon alpha-2 precursor; Interferon alpha-D; Interferon leukocyte; LeIF D; MGC138207; MGC138505; MGC138507;