The genes encoding type I interferons (IFNs), which include 14 IFN-alpha genes, 1 IFN-beta gene, 1 IFN-Omega (also known as IFN-alpha II1) gene, and a number of IFN-Omega pseudogenes, are clustered on human chromosome 9. Interferons-alpha and -beta are cytokines that are widely known to induce potent anti-viral activity. IFN-alpha and -beta exert a variety of other biological effects, including anti-tumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-Omega is antigenically different from human IFN-alpha, IFN-beta or IFN-gamma , but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells. The Type I interferon receptor (IFN-alphaR) interacts with IFN-alpha, IFN-beta and IFN-Omega, and seems to be a multisubunit receptor.