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IFNG, Recombinant, Human (Interferon gamma, IFN-gamma, Immune Interferon)

Cat no: 149640


Supplier: United States Biological
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IFN-g is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-g receptors are present in most immune cells, which respond to IFN-g signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-g signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-g stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-g species-specific and is biologically active only in human and primate cells. Recombinant human IFN-g is a 16.7kD protein containing 143aa. Recombinant protein corresponding to human IFN gamma, expressed in E. coli. Biological Activity: Determined in a viral resistance assay, the ED50 was found to be (same/less than)0.05ng/ml. Specific Activity: 2x10e7units/mg Endotoxin: (same/less than)0.1ng/ug (1EU/ug) Amino Acid Sequence: MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 149640
Size: 20ug
Form: Supplied as a lyophilized powder.
Purity: ~98% (SDS-PAGE and HPLC)

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