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Ikaros (C-terminus) mAb

Ikaros (C-terminus) mAb

Cat no: MB0092


Supplier: Bioworld Technology, Inc.
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Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs).
Catalogue number: MB0092
Reactivities: Human
Hosts: Mouse
Applications: Immunoprecipitation, Western Blot
Size: 100ug/100ul
Swiss prot: Q13422
Dilutions: WB: 1:1000 IP: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to the C-terminus of Human Ikaros.
Species: This antibody detects endogenous levels of Ikaros and does not cross-react with related proteins
Molecular weight: Predicted band size:58KDa Observed band size:58KDa
Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: IK1; LYF1; hIk-1; IKAROS; PRO0758; ZNFN1A1; Hs.54452; DNA-binding protein Ikaros
Additional info: For research use only, not for use in diagnostic procedure.

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