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IkB-alpha (Y42) Peptide

IkB-alpha (Y42) Peptide

Cat no: AP0643P

Supplier: Bioworld Technology, Inc.
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Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase alpha (IKKalpha), previously designated CHUK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation Serines 32 and 36. IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKalpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKalpha, IKKbeta and IKKgamma , and each appear to make essential contributions to IkB phosphorylation.
Catalogue number: AP0643P
Applications: Block/Neutralize/Inhibit
Swiss prot: P25963
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide IkB-alpha (Y42). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: I kappa B alpha; I kappa B alpha; I(Kappa)B(alpha); I(Kappa)B(alpha); I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; IKBA; IKBA; IKBalpha; MAD 3; MAD 3; MAD3; Major histocompatibility complex enhancer binding protein MAD3; Major histocompatibility complex enhancer binding protein MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappa-B inhibitor alpha; NFKBI; NFKBI; NFKBIA; NFKBIA; Nuclear factor of kappa light chain gene enhancer in B c
Additional info: This peptide can be used with studies using AP0643 IkB-alpha (Y42) pAb.

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