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IkB-(beta) (S23) pAb

IkB-(beta) (S23) pAb

Cat no: AP0636

Supplier: Bioworld Technology, Inc.
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The NF-kB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IkB proteins .Activation occurs via phosphorylation of IkB(alpha) at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-kB . IkB(alpha) phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IkB at these activating sites have been identified.The regulation of IkB(beta) and IkBE is similar to that of IkB(alpha). However, the phosphorylation and ubiquitin-mediated degradation of these proteins occurs with much slower kinetics. IKK phosphorylation of IkB(beta) occurs at Ser19 and Ser23, while IkBE can be phosphorylated at Ser18 and Ser22 .
Catalogue number: AP0636
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q15653
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to the N-terminal of Human IkB-(beta).
Species: IkB-(beta) (S23)
Molecular weight: ~ 48 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: I kappa B beta; IKB B; IKB beta; IKBB; IkBbeta; IkappaBbeta; NF kappa B inhibitor beta; NF kappa BIB; NFKBIB; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor beta; TR interacting protein 9; TRIP 9; TRIP9; Thyroid receptor
Additional info: For research use only, not for use in diagnostic procedure.

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