IkB-(beta) (S23) pAb

The NF-kB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IkB proteins .Activation occurs via phosphorylation of IkB(alpha) at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-kB . IkB(alpha) phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IkB at these activating sites have been identified.The regulation of IkB(beta) and IkBE is similar to that of IkB(alpha). However, the phosphorylation and ubiquitin-mediated degradation of these proteins occurs with much slower kinetics. IKK phosphorylation of IkB(beta) occurs at Ser19 and Ser23, while IkBE can be phosphorylated at Ser18 and Ser22 .

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SPECIFICATIONS

Catalog Number

AP0636

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to the N-terminal of Human IkB-(beta).

Species

IkB-(beta) (S23)

Dilutions

WB: 1:500~1:1000

Swiss Prot

Q15653

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 48 kDa

Alternative Names

I kappa B beta; IKB B; IKB beta; IKBB; IkBbeta; IkappaBbeta; NF kappa B inhibitor beta; NF kappa BIB; NFKBIB; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor beta; TR interacting protein 9; TRIP 9; TRIP9; Thyroid receptor