IkB-beta (S23) Peptide

The NF-kB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IkB proteins .Activation occurs via phosphorylation of IkBalpha at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-kB . IkBalpha phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IkB at these activating sites have been identified.The regulation of IkBbeta and IkBE is similar to that of IkBalpha. However, the phosphorylation and ubiquitin-mediated degradation of these proteins occurs with much slower kinetics. IKK phosphorylation of IkBbeta occurs at Ser19 and Ser23, while IkBE can be phosphorylated at Ser18 and Ser22 .

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SPECIFICATIONS

Catalog Number

AP0636P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide IkB-beta (S23). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q15653

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using AP0636 IkB-beta (S23) pAb.

Alternative Names

I kappa B beta; IKB B; IKB beta; IKBB; IkBbeta; IkappaBbeta; NF kappa B inhibitor beta; NF kappa BIB; NFKBIB; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor beta; TR interacting protein 9; TRIP 9; TRIP9; Thyroid receptor