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IKK(alpha) (M17) pAb

IKK(alpha) (M17) pAb

Cat no: BS1184


Supplier: Bioworld Technology, Inc.
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The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK(alpha) and IKK(beta) serve as the catalytic subunits of the kinase and IKK(gamma) serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK(beta) (Ser176 and Ser180 in IKK(alpha)), which causes conformational changes, resulting in kinase activation.

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