IL-10Ralpha (L492) Peptide

Cat no: BS1757P

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The IL-10 receptor, IL-10R, is a member of the class II subgroup of the cytokine receptor family and exhibits structural similarity to the interferon receptor. IL-10R is expressed in B cells and T helper cells, as well as in LPS-induced mouse fibroblasts. Overall, mouse IL-10R and human IL-10R share 60% sequence identity at the protein level. Stimulation with IL-10 leads to phosphorylation of JAK1 and Tyk 2 tyrosine kinases. The activated kinases phosphorylate the two tyrosine residues (Tyr 446 and Tyr 496) in the cytoplasmic domain of IL-10Ralpha. The phosphorylation of these two residues are required for proper function of IL-10R and activation of IL-10E1 signaling. IL-10Rbeta is ubiquitously expressed and, in addition to forming the IL-10 heterodimeric receptor, it forms a heterodimeric receptor with an IL-22R subunit and an IL-28R subunit. IL-10R is constitutively expressed on human natural killer (NK) cells and the direct binding of IL-10 potentiates cytokine production by human NK cells.

Catalogue number:	BS1757P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q13651
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide IL-10Ralpha (L492). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	IL-10R-A; IL-10R1; CDw210a antigen; IL10RA; IL10R
Additional info:	This peptide can be used with studies using BS1757 IL-10Ralpha (L492) pAb.

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IL-10Ralpha (L492) Peptide

Cat no: BS1757P

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