IL-11Ralpha (D361) Peptide

The pleiotropic cytokine, IL-11, has been shown to have proliferative and differentiation effects on lymphopoietic, myeloid and erythroid cells. IL-11 also has the inhibiting effect of repressing adipogenesis in vitro. The IL-11alpha receptor, IL-11Ralpha, is a member of the class 1 subgroup of the cytokine receptor family and exhibits structural similarity to the alpha subunits of the human ciliary neurotrophic factor (CNTF) and the mouse IL-6 receptor. It is speculated that the IL-11Ralpha regulates the proliferation and/or differentiation of skeletogenic progenitor and mesenchymal cells. Coexpression of gp130 and IL-11alpha is necessary for high-affinity binding of IL-11 to IL-11Ralpha. It has also been found that coexpression of IL-11Ralpha and gp130 is required for proper stimulation of Ba/F3 cells to differentiate into macrophage in response to IL-11.

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SPECIFICATIONS

Catalog Number

BS9265P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide IL-11Ralpha (D361). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q14626

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS9265 IL-11Ralpha (D361) pAb.

Alternative Names

CRSDA; hCG_2011440; I11RA; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA; IL11RA; Interleukin 11 receptor alpha; Interleukin 11 receptor alpha chain; Interleukin-11 receptor subunit alpha; MGC2146;