IL-12B (V277) pAb

IL-12 is secreted by macrophages and human B-lymphoblastoid cells in response to antigenic stimulation. This IL is responsible for the differentiation of naive CD4+ T cells into type 1 helper T cells that produce interferon-(gamma) (IFN-(gamma)). It also activates production of tumor necrosis factor (alpha) (TNF(alpha)) from T and natural killer (NK) cells, and it inhibits IL-4 mediated suppression of IFN-(gamma). IL-12 also has anti-angiogenic activity since the production of IFN-(gamma) increases the production of inducible protein-10 (IP-10). IL-12 p40 represents a subunit of IL-12 that is induced by several pathogens. IL-12 p70 is a subunit of IL-12 that is controlled through both the p35 and p40 genes in a cell type-specific fashion.

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SPECIFICATIONS

Catalog Number

BS3480

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 245-291 of Human IL-12B.

Species

IL-12B (V277) pAb detects endogenous levels of IL-12B protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

P29460

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 44 kDa

Alternative Names

Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; NKSF2; IL12B