The specific functions of different interleukins vary from the regulation of inflammatory and immune responses to the regulation of other interleukins. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. IL-17RC (interleukin-17 receptor C) is a 791 amino acid single-pass type I transmembrane protein that may function as a receptor for IL-17. Existing as multiple alternativelyspliced isoforms, IL-17RC is expressed in heart, brain, intestine, liver, kidney, lung, muscle, placenta and prostate, and is encoded by a gene which maps to human chromosome 3.