IL-2 pAb

Lymphokines are a group of signaling molecules involved in communication between cells of the immune system. Lymphokines secreted by activated lymphocytes include proteins such as IL-2. This protein is secreted primarily by helper T cells that have been activated through the T cell receptor complex or by other mitogens. Cells targeted by IL-2 include activated T helper and cytotoxic T cells, inducing their proliferation. The secretion of IL-2 can also act as a growth factor for B cells. To date, three different IL-2-dependent signal transduction pathways have been identified: the c-Fos/c-Jun induction pathway mediated by Src family protein-tyrosine kinases; the c-Myc induction pathway; and the Rapamycin-sensitive pathway; all of which result in the induction of Bcl-2. In addition, the transcription factor NFAT has been shown to play a major role in the regulation of IL-2 transcription and correlates to an age-related decline in the expression of IL-2.

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SPECIFICATIONS

Catalog Number

BS6422

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human IL-2.

Species

IL-2 pAb detects endogenous levels of IL-2 protein.

Dilutions

WB:1:500~2000\nIHC:1:50~200\nICC:1:50~200

Swiss Prot

P60568

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 18 kDa

Alternative Names

Aldesleukin; IL 2; IL-2; IL2; IL2; Interleukin 2; Interleukin-2; Involved in regulation of T cell clonal expansion; Lymphokine; OTTHUMP00000164090; POIL2; T Cell Growth Factor; T-cell growth factor; TCGF;