ILKAP (K71) pAb

ILKAP (integrin-linked kinase-associated serine/threonine phosphatase 2C),also known as PP2C(delta), is a 392 amino acid cytoplasmic protein phosphatase
that selectively interacts with integrin linked kinase (ILK) to regulate growth factor signaling and cell adhesion. While widely expressed, ILKAP is found at highest levels in striated muscle with lower levels found in smooth muscle.ILKAP belongs to the PP2C family and contains one PP2C-like domain. ILKAP has been suggested to inhibit oncogenic transformation and the ILK-GSK3(beta)signaling axis, and can bind two magnesium or manganese ions per subunit as cofactors. The gene encoding ILKAP maps to human chromosome 2,which consists of 237 million bases encoding over 1,400 genes and making up approximately 8% of the human genome.

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SPECIFICATIONS

Catalog Number

BS2359

Size

100ug/100ul

Applications

IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

he antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 40-90 of Human ILKAP.

Species

LKAP (K71)pAb detects endogenous levels of ILKAP protein.

Dilutions

WB: 1:500~1:1000\r\nIHC: 1:50~1:200 \r\nIF: 1:50~1:200

Swiss Prot

Q9H0C8

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul