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Integrin (alpha)4 (N1023) pAb

Integrin (alpha)4 (N1023) pAb

Cat no: BS2640

Supplier: Bioworld Technology, Inc.
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Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.
Catalogue number: BS2640
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P13612
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 1000-1032 of Human Integrin (alpha)4.
Species: ITGA4 (N1023) pAb detects endogenous levels of ITGA4 protein.
Molecular weight: ~ 115 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: ITGA4; 269C wild type; Alpha 4 subunit of VLA 4 receptor; Antigen CD49D; Antigen CD49D; alpha 4 subunit of VLA 4 receptor; CD 49d; CD49 antigen-like family member D; CD49d; CD49d antigen; CDw49d; IA4; Integrin alpha 4; Integrin alpha 4 subunit; Integrin alpha IV; Integrin alpha-4; Integrin alpha-IV; Integrin; alpha 4 (antigen CD49D; alpha 4 subunit of VLA 4 receptor); ITA4; ITGA 4; ITGA4; LPAM23; MGC90518; OTTHUMP00000205320; Very Late Activation Antigen 4; Very Late
Additional info: For research use only, not for use in diagnostic procedure.

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