Integrin (alpha)7 (E959) pAb

Integrins are heterodimers composed of noncovalently associated transmembrane (alpha) and (beta) subunits. The 16 (alpha) and 8 (beta) subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrinmediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

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SPECIFICATIONS

Catalog Number

BS7058

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 926-976 of Human Integrin (alpha)7.

Species

Integrin (alpha)7 (E959) pAb detects endogenous levels of Integrin (alpha)7 protein (129 kDa) and the Integrin (alpha)7 light chain (25 kDa).

Dilutions

WB: 1:500~1:1000

Swiss Prot

Q13683

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul