Integrin (alpha)V (P804) pAb

The integrin family contains at least 18 (alpha) and 8 (beta) subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling).Several (alpha)V subfamily members, including (alpha)V(beta)3, (alpha)V(beta)5, (alpha)V(beta)1, are highly expressed in active endothelial cells and cancer cells where they play a critical role in angiogenesis and tumor metastasis.

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SPECIFICATIONS

Catalog Number

BS3513

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 771-820 of Human Integrin (alpha)V.

Species

Integrin (alpha)V (P804) pAb detects endogenous levels of Integrin (alpha)V protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

P06756

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul