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Integrin (beta)5 (V746) pAb

Integrin (beta)5 (V746) pAb

Cat no: BS1188

Supplier: Bioworld Technology, Inc.
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Integrins are heterodimers composed of noncovalently associated transmembrane (alpha) and (beta) subunits. The 16(alpha) and 8(beta) subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses. In addition to mediating cell adhesion and cytoskeletal organization, Integrins function as signaling receptors. Signals transduced by Integrins play a role in many ?biological processes, including cell growth, differentiation, migration and apoptosis.
Catalogue number: BS1188
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P18084
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 720-770 of Human Integrin (beta)5.
Species: Integrin (beta)5 (V746) pAb detects endogenous levels of Integrin (beta)5 protein.
Molecular weight: ~ 88 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Integrin beta-5; ITGB5
Additional info: For research use only, not for use in diagnostic procedure.

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