Interferon Beta (IFN-beta, Ifnb1, Ifb, Ifnb)

interferon beta (IFN Beta), a 22kD cytokine with wide-ranging antiviral, antimicrobial and antitumor effects. Interferons also serve to activate macrophages, natural killer cells and the presentation of antigens to the immune system by the major histocompatibility complex. The production of interferon is induced in response to microbes and other cytokines. The interferons are widely used to treat a variety of diseases and IFNB in particular is used to treat relapsing-remitting multiple sclerosis.\n\nApplications:\nSuitable for use in Neutralization, ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

I7662-10P

Size

20KU

Applications

ELISA, IHC, IP, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in 0.3M NaHCO3, 0.2M sodium chloride.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

1. Asselin-Paturel et al. (J Exp. Med, 2005) used 32400 in combination with Rabbit mouse IFN-alpha (32100) to explore the role of Type I IFN in the migration and activation of dendritic cells. Kamath et al. (J. Immunol. 2005) used a similar cocktail to demonstrate that dendritic cell derived Type I IFN stimulates bystander T-cells. 2. Seimon et al. (P.N.A.S, 2006) used 32400 to examine the role of IFN-Beta in protecting LPS treated macrophages from apoptosis. Zheng et al. (J. Biol. Chem, 2006) used 32400 to examine the role of autocrine IFN-Beta in RANKL stimulated iNOS expression in macrophages.

Additional Info

Recognizes mouse interferon beta.