Interferon beta, Recombinant, Mouse (CHO) (IFNb)

Three types of interferons have been described: interferon-alpha (IFN-alpha), interferon-beta (IFN-beta), and interferon-gamma (IFN-gamma). An extensive variety of biological effects have been observed for the interferon family including antiviral activity; anti-proliferative activity; stimulation of cytotoxic activities in lymphocytes, natural killer cells, and macrophages; and modulation of the major histocompatibility complex. Only one mouse-IFN-beta gene has yet been described. It codes for a 161 amino acid polypeptide (20kD). Mouse-IFN-beta binds to the type I interferon receptor. It is not recognized by antibodies directed against mouse\nalpha interferon or mouse gamma interferon.\n\nOne unit of mouse beta interferon is the amount of beta interferon which protects 50% of the indicator cell population from viral destruction. One unit of Mouse Beta Interferon approximates the bioactivity contained in one unit of the mouse beta interferon standard prepared by NIH (Gb02-902-511).\n\nSource:\nMouse, CHO-derived\n\nRecommended Dilution:\nFor dilutions use a buffer containing 2% bovine serum albumin or culture medium. (Do not use fresh serum.)\n\nStorage and Stability:\nLyophilized powder may be stored at-20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with 1ml distilled or de-ionized water. Aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. Note: mouse IFN-beta is highly labile when agitated.

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SPECIFICATIONS

Catalog Number

I7662-11B

Size

5KU

Form

Supplied as a lyophilized powder in PBS, 10% mouse albumin, 0.01% gelatin. Reconstitute the vial by injection of 1 ml distilled or de-ionized water (Caution: vial is under vacuum).

Purity

Purified

References

1. De Maeyer, E et al; Interferons and Other Regulatory Cytokines, 1st ed., 1988, Wiley and Sons, New York 2. Vonk, W et al; Large-scale, one-step purification of murine interferon-beta using a monoclonal antibody. J of Interferon Res 1983, 3: 169