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Interleukin 1 beta (IL-1b)

Cat no: I7663-24M

Interleukin 1 beta (IL-1b)

Interleukin 1 beta (IL1 beta) is a pro-inflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursors. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. Recent studies have shown IL1 beta to be a major cause of severe inflammation in the mouse model of Crohn

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SPECIFICATIONS

Catalog Number

I7663-24M

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid.

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

1.March CJ, et al. Nature 315:641-647, 1985.2.Dinarello CA, et al. Blood 87:2095-2147, 1996.3.Yuan J, et al. Cell 75:641-652, 19934.Shin M, et al. Science 4:734-738, 2005.

Additional Info

Recognizes human IL-1 beta protein

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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