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Interleukin 1 Receptor Antagonist, Recombinant, Human (IL-1RA)

Cat no: I7663-25N3

Interleukin 1 Receptor Antagonist, Recombinant, Human (IL-1RA)

One of the most potent pro-inflammatory mediators is the early-acting cytokine interleukin-1 (IL-1), whose actions are regulated by the structurally related IL-1 receptor antagonist (IL-1 RA). IL-1 RA is a competitive IL-1 inhibitor and a powerful anti-inflammatory agent. Also, Several autoimmune and inflammatory diseases have been associated with an allelic polymorphism of the IL-1 RA gene. Recombinant human IL-1 RA was expressed in E. coli and consists of 153 amino acids.\n\nAA Sequence:\nMRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

I7663-25N3

Size

50ug

Form

Supplied as a liquid in PBS, pH 7.4.

Purity

~95% by SDS-PAGE. Purified by using conventional chromatography techniques.

References

1. Capper, et al. Clin. Exp. Immunol. 138: 348 (2004). 2. Roberge, C.J., et al., Journal of Immunology 152: 5485-5494 (1994). 3. Carter, D.B., et al., Nature 344: 633-637 (1990).

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