Interleukin 10, Human, Low Range (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) BioAssay(TM) ELISA Kit

Interleukin 10 (IL-10), initially designated cytokine synthesis inhibitory factor (CSIF), was originally identified as a product of murine TH2 clones that suppressed the production of cytokines by TH1 clones responding to stimulation by antigen in the presence of monocyte/macrophage antigen-presenting cells. The human homolog of murine IL-10 was subsequently cloned by cross-hybridization. Human and murine IL-10 are 81% and 73% identical at the nucleotide and amino acid levels, respectively. Both mouse and human IL-10 are also highly homologous to a previously uncharacterized open reading frame in the Epstein-Barr virus (EBV) genome, BCRF1. The BCRF1 gene product is now designated viral IL-10. In mouse, IL-10 is produced by TH2 cells, activated fetal thymocytes, macrophages, keratinocytes, and LY-1+ (CD5+) and normal B cells. Cell lines found to have the capacity to produce IL-10 in humans include: TH0, TH1, and TH2-like CD4+ T cell clones; B cell lines derived from patients with AIDS and Burkitt

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SPECIFICATIONS

Catalog Number

I8432-05

Size

96Tests

Applications

ELISA

Reactivities

Hum

References

1. Moore, K., et al., Annu. Rev. Immunol. 11: 165-190 (1993). 2. Yssel, H., et al., J. Exp. Med. 174: 593 (1991). 3. de Waal, M.R., et al., J. Exp. Med. 174: 915 (1991). 4. de Waal, M.R., et al., J. Exp. Med. 174: 1209 (1991). 5. Florentino, D.F., et al., J. Immunol. 146: 3444 (1991). 6. Florentino, D.F., et al., J. Immunol. 147: 3815 (1991). 7. Niiro, H., et al., Int. Immunol. 6: 661 (1994). 8. de Waal, M.R. & Moore, K.M., The Cytokine Handbook, 3rd edn, (Ed, A. Thompson), Interleukin-10, p. 333-346, Academic Press, London (1988). 9. Grutz, G., J. Leukoc. Biol. 77: 3-15 (2005). 10. Windsor, W.T., et al., Biochemistry 32: 8807-8815 (1993).