Interleukin 12, p40, Recombinant, Human (IL-12)

Interleukin-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23. Recombinant human IL-12 p40 is a 40kD protein containing 306 amino acid residues.\n\nStability:\nThe lyophilized protein is stable for a few weeks at room temperature, but best stored at -200C. Reconstituted IL-12 p40 should be stored in working aliquots at -200C.\n\nPurity:\n(same/more than) 95% by SDS-PAGE and HPLC analyses.\n\nEndotoxin:\n(same/less than) 0.1ng per ug (1EU/ug).\n\nBiological Activity:\nNot available\n\nAA Sequence:\np40-Sub unit --IWELKKDV YVVELDWYPD APGEMVVLTC DTPEEDGITW TLDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSHS LLLLHKKEDG IWSTDILKDQ KEPKNKTFLR CEAKNYSGRF TCWWLTTIST DLTFSVKSSR GSSDPQGVTC GAATLSAERV RGDNKEYEYS VECQEDSACP AAEESLPIEV MVDAVHKLKY ENYTSSFFIR DIIKPDPPKN LQLKPLKNSR QVEVSWEYPD TWSTPHSYFS LTFCVQVQGK SKREKKDRVF TDKTSATVIC RKNASISVRA QDRYYSSSWS EWASVPCS\n\nCountry of Origin:\nUSA

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SPECIFICATIONS

Catalog Number

I8434-31B

Size

2ug

References

1. Mattner, F., S. Fisher, S. Guckes, S. Jin, H. Kaulen, E. Schmitt, E. Rude, and T. Germann (1993) The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23(9):2202-2208.\n\n2. Locksley, R. M. (1993) Interleukin-12 in host defense against microbial pathogens. Proc. Nat