Interleukin 12, Recombinant, Human (IL-12, Cytotoxic Lymphocyte Maturation Factor 1, CTL Maturation Factor, TcMF, CLMF p35, Natural Killer Cell Stimulatory Factor 1, NFSK1, p35, T cell Stimulating Factor, TSF) (Human 293 Cells)

Human Cell Expression Cytokines:\nExpression of proteins in our Human 293-cell expression system is a cost-effective and scalable production method for high-authenticity, recombinant human proteins.\n\nFunctional activities of human proteins depend on proper folding, phosphorylation, disulfide bridge formation, and proteolytic processing or appropriate glycosylation. Ideally, recombinant human proteins are produced in human cells that are more authentic in terms of both physical properties and biochemical functions. However, the current process of human cell expression requires a large quantity of DNA and medium supplemented with bovine serum. Hence, it is often a daunting task to produce sufficient amount of high quality proteins for drug discovery or diagnostic development (1-100mg) at acceptable cost. United States Biological is now supplying a high yield, cost-effective and versatile system to produce active recombinant human proteins in a human cell line to meet the special needs of the broad scientific community and drug discovery industry. In this system, we have broken key bottleneck steps to increase protein production and reduce cost, including\n\n

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SPECIFICATIONS

Catalog Number

I8434-01B

Size

10ug

Form

Supplied as a lyophilized powder from PBS. Reconstitute with sterile PBS, 0.1% endotoxin-free recombinant HSA (cat #A1327-54A). Endotoxin:(same/less than)1EU/ug

Purity

(same/more than)95% as determined by SDS-PAGE and Coomasssie blue staining.\n

References

1. Gately, M. K., et al. (1998) Annu. Rev. Immunol. 16: 495-521. 2. Hodge, D. L., et al. (2002) Mol. Cell. Biol. 22: 1742-1753.