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Interleukin 13, Recombinant, Mouse (IL-13, NC30)

Cat no: 142894

Interleukin 13, Recombinant, Mouse (IL-13, NC30)

Interleukin-13 (IL-13) is an important cytokine secreted from Th2 cells. The functions attributed to IL-13 overlap significantly with those of IL-4 (induces IgE secretion from B cells and inhibits expression of inflammatory cytokines such as IL-1b, TNF-a, IL-8 and IL-6), but differs from IL-4 in that IL-13 seems to link inflammatory response of immune cells to the pathophysiological changes in the surrounding non-immune cells. The receptor subunits of IL-13 consist of IL-4Ra, IL-13Ea1 and IL-13Ra2. Human and mouse IL-13 are cross-reactive.\n\nSource:\nRecombinant protein corresponding to 111aa from mouse IL-13 expressed in E.coli.\n\nMolecular Weight: \n~12.3kD\n\nEndotoxin:\n(same/less than)1EU/ug (LAL)\n\nBiological Activity:\nThe activity is determined by the dose dependent proliferation of TF-1 cells and is typically <4ng/ml.\n\nAA Sequence:\nMPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F\n\nStorage and Stability: \nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

142894

Size

2ug

Form

Supplied as a lyophilized powder no additives. Reconstitute with sterile dH2O.

Purity

~95% (Reducing and non-reducing SDS-PAGE).

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