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Interleukin 15, aa49-162, Recombinant, Mouse

Cat no: I8437-05D

Interleukin 15, aa49-162, Recombinant, Mouse

Interleukin 15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity and has structural similarity to IL-2 that is secreted by mononuclear phagocytes following infection by viruses. Stimulation by IL-15 requires interaction of Il-15 with components of IL-2R, including IL-2Rbeta and probably IL-2R gamma, but not IL-2R alpha. This cytokine is produced by a wide variety of cells and tissues and like IL-2, stimulates the proliferation of T-lymphocytes and induces the generation of cytotoxic T-lymphocytes (CTLs) and lymphokine-activated killer (LAK) cells. Recombinant human IL-15 was expressed in E.coli and purified by using conventional chromatography after refolding of the isolated inclusion bodies in a redox buffer.\n\nSource: Recombinant human IL-15, aa49-162, His-tagged, expressed in E.coli\n\nMolecular Weight: 17.6 kD (152aa) \n\nAA Sequence:\nMRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMNW IDVRYDLEKI ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH\nEYSNMTLNET VRNVLYLANS TLSSNKNVAE SGCKECEELE EKTFTEFLQS FIRIVQMFIN TS\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. .

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SPECIFICATIONS

Catalog Number

I8437-05D

Size

50ug

Form

Supplied as a liquid in PBS, pH 7.4, 10% glycerol.

Purity

(same/more than)90% by SDS-PAGE

References

1. Ozawa A., et al. (2009). J immunol. 183(3):2193, 2. Olsen SK., et al. (2007). J Biol Chem. 282(51):37191-204.

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