Interleukin 15, Recombinant, Human (IL-15)

Interleukin-15 (IL-15) is an immunomodulating cytokine that stimulated the proliferation of T lymphocytes. It shares many biological properties with IL-2. IL-5 is a potent lymphoid cell growth factor that exerts its biological activities primarily on T cells. It is essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, imflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is a 12.9 kD protein containing 114 amino acid residues.\n\nBiological Activity: \nFully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be (same/less than)\n0.5ng/ml, corresponding to a specific activity of (same/more than)2x10e6 units/mg.\n\nAmino Acid Sequence:\nMNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS\n\nResponding Cells (partial list):\nT cells, NK cells, LAK cells\n\nRecommended Dilutions: \nMost in vitro applications, IL-15 exerts its biological activity in the concentration range of 0.1-10ng/ml. Optimal dilutions to be determined by researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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