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Interleukin 15, Recombinant, Human (IL-15, IL-T)

Cat no: 142895

Interleukin 15, Recombinant, Human (IL-15, IL-T)

Interleukin 15 (IL-15) is a widely expressed pro-inflammatory cytokine related to IL-2. neutrophils and macrophages and is critical to dendritic cell function in several model systems. IL-15 has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggests that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes. Human IL-15 shows activity on mouse cells. \n\nSource:\nRecombinant protein corresponding to 114aa from human IL-15 expressed in E.coli. \n\nMolecular Weight: \n12.8kD\n\nEndotoxin:\n(same/less than)1EU/ug (LAL)\n\nBiological Activity:\nThe activity is determined by the dose-dependant stimulation of the proliferation of mouse CTLL-2 cells and is typcially <0.5ng/ml.\n\nAA Sequence:\nMNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

142895

Size

2ug

Form

Supplied as a lyophilized powder in 10mM sodium biocarbonate, pH 8.0. Reconstitute with sterile dH2O.

Purity

~98% (HPLC, Reducing and non-reducing SDS-PAGE)

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